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Agenda
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Day 1 - 14th April
| 09:00 | Plenary Session | Assembly Room |
Chairs – Professor Chris McGuigan (Welsh School of Pharmacy, Cardiff University) |
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| 09:00 | Welcome address | |
Dame Deidre Hine (Chair, Partners Forum, Wales Cancer Institute) |
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| 09:15 | S01 Clofarabine: A Success Story | |
Professor Christopher Wood (Executive Chairman, Nucana Biomed Ltd) |
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| 10:05 | S02 Tobacco cessation: latest findings | |
Professor Robert West (Cancer Research UK Health Behavior Research Centre, |
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| 10:55 to 11:15 | Refreshments | Lower Hall, Marble Hall |
Parallel Sessions |
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| 11:15 - 12:45 | 1) Cancer policy in Wales | Council Chamber |
S03 Question and answer session with Key Welsh Assembly Members Chair – Hywel Griffith (Health Correspondent, BBC Wales) Panel
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| 11:15 - 12:45 | 2) Genomic instability | Assembly Room |
Chair – Dr Duncan Baird (CR UK Senior Fellow and Reader, School of Medicine, Cardiff University) |
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| 11:15 | S04 Removal of covalent bound topoisomerases from DNA by MRN and Ctp1: implications for cancer drug resistance mechanisms | |
Dr Edgar Hartsuiker (Bangor University) |
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| 11:45 | S05 Yeast NER factors function at the interface of DNA repair and the DNA checkpoint | |
Dr Simon Reed (Non-Clinical Reader, School of Medicine, Cardiff University) |
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| 12:15 | S06 The effect of telomerase on the genomic instability and bystander signalling which is induced by low doses of CR (VI) | |
Dr Charles Patrick Case (Bristol Implant Research Centre, Avon Orthopaedic Centre, Southmead Hospital, Bristol) |
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| 11:15 – 12:45 | 3) Clinical Trials Showcase (Session sponsored by Q Chip Ltd) | Syndicate Room D |
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| 11:20 | S07 Trials in locally advanced rectal cancer: RICE, EXITE and ARISTOTLE | |
Dr Simon Gollins (Consultant Clinical Oncologist, North Wales Cancer Treatment Centre, Rhyl) |
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| 11:40 | S08 Results from the MRC COIN Trial of first-line therapy for advanced colorectal cancer | |
Professor Tim Maughan (Professor of Cancer Studies, Consultant Clinical Oncologist, Velindre Hospital, Cardiff) |
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| 12:00 | S09 FRAGMATIC: A randomized phase III study investigating the effect of FRAGMIN added to standard therapy to patients with lung cancer | |
Dr Simon Noble (Clinical Senior Lecturer in Palliative Medicine, Royal Gwent Hospital) |
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| 12:20 | S10 A new method to analyze randomized clinical trials | |
Dr Marc Buyse (CEO and Founder, International Drug Development Institute, Louvain-La-Neufe, Belgium) |
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| 11:15 – 12:45 | 4) Palliative care: a patient orientated approach (Question and answer session) |
Syndicate Room C |
Chair – Stephanie Jones (Wales Cancer Trials Network Consumer representative) |
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| 11:20 | S11 Overview of end of life care strategies across the UK and lessons for Wales | |
Dr Rachael Addicott (Senior Research Fellow, King’s Fund, London) |
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| 11:40 | S12 District and community nurse palliative & end of life care project Cardiff and Vale Health Board Pilot | |
Mel Lewis (Lead Nurse Palliative Care, Cardiff and Vale University Local Health Board) |
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| 12:00 | S13 Establishing equitable access for patients to palliative care research: looking for a Welsh solution | |
Dr Anthony Byrne (Medical Director, Marie Curie Cancer Care) |
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| 12:20 | Questions to the panel | |
| 12:45 | Lunch and poster viewing | Lower Hall, Marble Hall |
Parallel Sessions |
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| 11:15 – 12:45 | 5) Cell signalling and human cancer (Sponsored by sanofi-aventis) | Syndicate Room D |
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| 14:00 | S14 PI 3-kinase signalling in human cancer | |
Professor Peter Downes (Principal and Vice-Chancellor, University of Dundee, Dundee) |
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| 14:45 | P17 Absence of the Birt Hogg Dubé gene product is associated with increased Hypoxia Inducible Factor transcriptional activity and a Warburg effect | |
Dr Andy Tee (Institute of Medical Genetics, Cardiff University) |
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| 15:00 | P18 Cell-based screening for inhibitors of the WNT signalling pathway | |
Dr Kenneth Ewan (School of Biosciences, Cardiff University) |
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| 15:15 | P19 A trial of the safety and efficacy of sirolimus in the treatment of renal angiomyolipomas in tuberous sclerosis and sporadic lymphangioleiomyomatosis | |
Dr Mark Davies (Institute of Medical Genetics, Wales College of Medicine, Cardiff University) |
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| 14:00 – 15:30 | 6) Molecular therapy (Sponsored by Abraxis BioScience) | Syndicate Room L |
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| 14:00 | S15 Overview of personalised medicine in colorectal cancer and the “COIN Trial” experience | |
Dr Richard Adams (Senior Lecturer in Clinical Oncology, Velindre Cancer Centre, Velindre Hospital, Cardiff) |
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| 14:15 | S16 The NCRI Adjuvant Breast Cancer (ABC) Trial - Towards personalised therapy for breast cancer | |
Professor Peter Barrett-Lee (Consultant and Clinical Oncologist, Velindre Cancer Centre, Velindre Hospital, Cardiff) |
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| 14:40 | Lung cancer and molecular medicine | |
Dr Dean Fennell (Consultant and Senior Lecturer, Centre for Cancer Research and Cell Biology, Queens University, Belfast) |
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| 15:05 | S17 Endocrine resistance in breast cancer – new targets | |
Dr Steven Hiscox (RCUK Academic Fellow, Welsh School of Pharmacy, Cardiff University) |
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| 14:00 – 15:30 | 7) Drug discovery and development – an introductory guide | Syndicate Room C |
Chair – Professor Chris McGuigan (Welsh School of Pharmacy, Cardiff University) |
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| 14:00 | S18 Molecular graphics and computer visualisation in (cancer) drug discovery | |
Dr Andrea Brancale (Lecturer in Medicinal Chemistry, Welsh School of Pharmacy, Cardiff University) |
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| 14:20 | S19 Irrational drug discovery: stumbling and (sometimes) finding | |
Professor Chris McGuigan (Welsh School of Pharmacy, Cardiff University) |
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| 14:40 | S20 Modeling colon cancer progression in the mouse | |
Professor Alan Clarke (Professor of Mammalian Genetics, Cardiff School of Biosciences, Cardiff University) |
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| 15:00 | S21 Clinical trials of new drugs | |
Professor Alan Burnett (Head of Department – Haematology, University Hospital of Wales, Cardiff University) |
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| 15:20 | Questions and answers | |
| 14:00 – 15:30 | 8) Picture of cancer in Wales | Assembly Room |
Chair – Dr Ian Lewis (Scientific Director, Tenovus) |
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| 14:00 | S22 Cancer trends in Wales, 1991-2008 | |
| Dr Ceri White (Lead Statistician, Wales Cancer Intelligence Surveillance Unit) |
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| 14:20 | S23 How the cancer genetics service for Wales is improving the patient experience | |
| Dr Alexandra Murray (Clinical Lead, Cancer Genetics Service for Wales) |
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| 14:40 | The Wales Cancer Trials Network: a decade of trials and tribulations | |
Professor John Wagstaff (Director, Wales Cancer Trials Network) |
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| 15:00 | S24 The Wales Cancer Bank and it’s potential in drug development: target and hypothesis validation from a population-based tissue collection | |
| Professor Malcolm Mason (Director, Wales Cancer Bank) |
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| 15:20 | Questions and answers | |
| 14:00 – 15:30 | 9) Children and young people with cancer | Syndicate Room B |
Chair – Simon Morgan-Jones (Service Manager for Wales, CLIC Sargent) |
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| 14:00 | S25 ‘More than my illness’ – Delivering quality care for young people with cancer | |
Simon Morgan-Jones (Service Manager for Wales, CLIC Sargent) |
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| 14:35 | S26 The needs of children when a parent or grandparent has cancer | |
Michele Pengelly (Specialist Nurse, Supportive Care, Velindre Cancer Centre) |
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| 14:55 | Questions and answers | |
| 15:30 – 15:50 | Refreshment Break | Lower Hall, Marble Hall |
| 15:50 | Plenary session | Assembly Room |
Chair – Dr Andrew Westwell (Senior Lecturer in Medicinal Chemistry, Welsh School of Pharmacy, Cardiff University) |
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| 15:50 | S27 Drug discovery – Translating drug discovery out of an academic setting: options and experience | |
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| 16:40 | Plenary session | Assembly Room |
Chairs – Libby Batt (Associate Director, Wales Cancer Trials Network) Patient Panel, sharing their experience and views of clinical research John Albert Evans (Member of Patient Panel, Wales Cancer Trials Network) |
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| 17:30 | Poster viewing and drinks reception | Lower Hall |
Chair – Professor John Wagstaff (Director, Wales Cancer Trials Network)
Chair – Professor Julian Sampson (Institute of Medical Genetics, Wales College of Medicine, Cardiff University)
Chair – Dr Richard Adams (Senior Lecturer in Clinical Oncology, Velindre Cancer Centre, Velindre Hospital, Cardiff)
(Sponsored by British Association for Cancer Research) 
