Dr. Andrew Tee
Dr Andrew R. Tee BSc PhD (Non-Clinical Research Lecturer/AICR Fellow, Medical Genetics, Cardif University)
Career Profile
I received a 1 st class BSc. Honors in Biochemistry at the University of Dundee in 1998. I then started my career dissecting mammalian target of rapamycin (mTOR) signalling during my Ph.D studies at the University of Dundee as a Wellcome Trust Prize Student. This line of research took me to Prof. John Blenis's lab at Harvard, where I carried out an EMBO Postdoctoral Fellowship working on aspects of Tuberous Sclerosis and mTOR signalling. More recently in 2007, I was awarded a 6 year prestigious Career Development Fellowship from the Association of International Cancer Research that supports my lab in the Medical Genetics Department at Cardiff University.
Research Interests
mTOR plays a broad role in cancer progression and involves cell cycle progression, cell growth, gene expression, autophagy (recycling of cellular components), mitrochondrial biogenesis/glycolysis (cellular energy production), apoptosis (controlled cellular death), angiogenesis (hypoxia-mediated blood vessel growth), and nutrient uptake. Heightened mTOR activity contributes to the pathology of many human diseases that cause cancer. To understand how mTOR-regulated cellular processes are disregulated in human disease, our lab is undergoing research projects to identify and characterise molecular proteins that are regulated by mTOR.